Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

[Image: see text] The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant molecules can be poor. This liability was see...

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Detalles Bibliográficos
Autores principales: Drewry, David H., Annor-Gyamfi, Joel K., Wells, Carrow I., Pickett, Julie E., Dederer, Verena, Preuss, Franziska, Mathea, Sebastian, Axtman, Alison D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802302/
https://www.ncbi.nlm.nih.gov/pubmed/34333981
http://dx.doi.org/10.1021/acs.jmedchem.1c00440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802302/
https://www.ncbi.nlm.nih.gov/pubmed/34333981
http://dx.doi.org/10.1021/acs.jmedchem.1c00440

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