p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II

p21-Activated kinase-1 (Pak1) is frequently overexpressed and/or amplified in human breast cancer and is necessary for transformation of mammary epithelial cells. Here, we show that Pak1 interacts with and phosphorylates the Calcium/Calmodulin-dependent Protein Kinase II (CaMKII), and that pharmacol...

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Detalles Bibliográficos
Autores principales: Saldivar-Cerón, Héctor I., Villamar-Cruz, Olga, Wells, Claire M., Oguz, Ibrahim, Spaggiari, Federica, Chernoff, Jonathan, Patiño-López, Genaro, Huerta-Yepez, Sara, Montecillo-Aguado, Mayra, Rivera-Pazos, Clara M., Loza-Mejía, Marco A., Vivar-Sierra, Alonso, Briseño-Díaz, Paola, Zentella-Dehesa, Alejandro, Leon-Del-Rio, Alfonso, López-Saavedra, Alejandro, Padierna-Mota, Laura, Ibarra-Sánchez, María de Jesús, Esparza-López, José, Hernández-Rivas, Rosaura, Arias-Romero, Luis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802317/
https://www.ncbi.nlm.nih.gov/pubmed/35111748
http://dx.doi.org/10.3389/fcell.2021.759259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802317/
https://www.ncbi.nlm.nih.gov/pubmed/35111748
http://dx.doi.org/10.3389/fcell.2021.759259

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