MYCN upregulates the transsulfuration pathway to suppress the ferroptotic vulnerability in MYCN-amplified neuroblastoma

Ferroptosis is an iron-dependent, oxidative form of cell death that is countered mainly by glutathione peroxidase 4 (GPX4) and the production of glutathione (GSH), which is formed from cysteine. The identification of the cancers that may benefit from pharmacological ferroptotic induction is just eme...

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Detalles Bibliográficos
Autores principales: Floros, Konstantinos V., Chawla, Ayesha T., Johnson-Berro, Mia O., Khatri, Rishabh, Stamatouli, Angeliki M., Boikos, Sosipatros A., Dozmorov, Mikhail G., Cowart, L. Ashley, Faber, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2022
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802432/
https://www.ncbi.nlm.nih.gov/pubmed/35174317
http://dx.doi.org/10.15698/cst2022.02.264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802432/
https://www.ncbi.nlm.nih.gov/pubmed/35174317
http://dx.doi.org/10.15698/cst2022.02.264

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