Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells

BACKGROUND: Ceramide, important for both neuronal differentiation and dedifferentiation, resides in several membranes, is synthesized in the endoplasmic reticulum, mitochondrial, and nuclear membranes, and can be further processed into glycosphingolipids or sphingomyelin. Ceramide may also be genera...

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Detalles Bibliográficos
Autores principales: Kagan, Terri, Stoyanova, Gloria, Lockshin, Richard A., Zakeri, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802477/
https://www.ncbi.nlm.nih.gov/pubmed/35101031
http://dx.doi.org/10.1186/s12964-021-00767-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802477/
https://www.ncbi.nlm.nih.gov/pubmed/35101031
http://dx.doi.org/10.1186/s12964-021-00767-2

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