Selective activation of PFKL suppresses the phagocytic oxidative burst

In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens. However, excessive NOX2 activity can exacerbate inflammation, as in acute respiratory distress s...

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Detalles Bibliográficos
Autores principales: Amara, Neri, Cooper, Madison P., Voronkova, Maria A., Webb, Bradley A., Lynch, Eric M., Kollman, Justin M., Ma, Taylur, Yu, Kebing, Lai, Zijuan, Sangaraju, Dewakar, Kayagaki, Nobuhiko, Newton, Kim, Bogyo, Matthew, Staben, Steven T., Dixit, Vishva M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802628/
https://www.ncbi.nlm.nih.gov/pubmed/34320407
http://dx.doi.org/10.1016/j.cell.2021.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802628/
https://www.ncbi.nlm.nih.gov/pubmed/34320407
http://dx.doi.org/10.1016/j.cell.2021.07.004

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