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Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors
Cyclic nucleotide phosphodiesterases (PDEs) have been proven to be targets for which highly selective and potent drugs can be developed. Mammalian genomes possess 21 genes whose products are pharmacologically grouped into 11 families; however related genes from pathogenic organisms display sufficien...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802716/ https://www.ncbi.nlm.nih.gov/pubmed/35111072 http://dx.doi.org/10.3389/fphar.2021.833156 |