Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4

WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified...

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Detalles Bibliográficos
Autores principales: Luo, Jiansong, De Pascali, Francesco, Richmond, G. Wendell, Khojah, Amer M., Benovic, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802859/
https://www.ncbi.nlm.nih.gov/pubmed/34973340
http://dx.doi.org/10.1016/j.jbc.2021.101551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802859/
https://www.ncbi.nlm.nih.gov/pubmed/34973340
http://dx.doi.org/10.1016/j.jbc.2021.101551

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