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Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4

WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified...

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Detalles Bibliográficos
Autores principales:	Luo, Jiansong, De Pascali, Francesco, Richmond, G. Wendell, Khojah, Amer M., Benovic, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802859/ https://www.ncbi.nlm.nih.gov/pubmed/34973340 http://dx.doi.org/10.1016/j.jbc.2021.101551

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