Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson–Gilford progeria syndrome

AIMS: Hutchinson–Gilford progeria syndrome (HGPS) is an ultrarare laminopathy caused by expression of progerin, a lamin A variant, also present at low levels in non-HGPS individuals. HGPS patients age and die prematurely, predominantly from cardiovascular complications. Progerin-induced cardiac repo...

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Detalles Bibliográficos
Autores principales: Macías, Álvaro, Díaz-Larrosa, J Jaime, Blanco, Yaazan, Fanjul, Víctor, González-Gómez, Cristina, Gonzalo, Pilar, Andrés-Manzano, María Jesús, da Rocha, Andre Monteiro, Ponce-Balbuena, Daniela, Allan, Andrew, Filgueiras-Rama, David, Jalife, José, Andrés, Vicente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803078/
https://www.ncbi.nlm.nih.gov/pubmed/33624748
http://dx.doi.org/10.1093/cvr/cvab055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803078/
https://www.ncbi.nlm.nih.gov/pubmed/33624748
http://dx.doi.org/10.1093/cvr/cvab055

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