CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies

As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies, is critical to the advancement of the field. In contrast to monovalent antibodies, which consist of two identical antigen-binding sites, bispecific antibodies can ta...

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Kroell, Katharina B., Grunewald, Lukas J., Fischer, Anna-Lena M., Riccabona, Jakob R., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803122/
https://www.ncbi.nlm.nih.gov/pubmed/35090383
http://dx.doi.org/10.1080/19420862.2021.2024118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803122/
https://www.ncbi.nlm.nih.gov/pubmed/35090383
http://dx.doi.org/10.1080/19420862.2021.2024118

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