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A high-dose inoculum size results in persistent viral infection and arthritis in mice infected with chikungunya virus
Chikungunya virus (CHIKV) is an emerging mosquito-transmitted alphavirus that leads to acute fever and chronic debilitating polyarthralgia. To date, the mechanism underlying chronic recurrent arthralgia is unknown. In the present study, newborn wild-type C57BL/6 mice were infected with CHIKV, and th...
Autores principales: | Zhang, Yue, Yan, Hu, Li, Xian, Zhou, Dihan, Zhong, Maohua, Yang, Jingyi, Zhao, Bali, Fan, Xuxu, Fan, Jun, Shu, Jiayi, Lu, Mengji, Jin, Xia, Zhang, Ejuan, Yan, Huimin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803182/ https://www.ncbi.nlm.nih.gov/pubmed/35100271 http://dx.doi.org/10.1371/journal.pntd.0010149 |
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