Sortilin drives hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress

Sortilin is a glycoprotein mainly known for its role as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. Its actual contribution to essential hypertension has remained hitherto elusive. Combining top-notch in vivo, ex vivo, and in vitro approache...

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Detalles Bibliográficos
Autores principales: Varzideh, Fahimeh, Jankauskas, Stanislovas S., Kansakar, Urna, Mone, Pasquale, Gambardella, Jessica, Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803317/
https://www.ncbi.nlm.nih.gov/pubmed/35104807
http://dx.doi.org/10.1172/JCI156624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803317/
https://www.ncbi.nlm.nih.gov/pubmed/35104807
http://dx.doi.org/10.1172/JCI156624

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