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A forced marriage of IL-2 and PD-1 antibody nurtures tumor-infiltrating T cells

IL-2 is a pleiotropic cytokine. In this issue of the JCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti–PD-1 (PD-1–laIL-2) that reactivates intratumoral CD8(+) T cells, but not CD4(+) Treg cells. PD-1–laIL-2 treatment synergized with anti–PD-L1 therapy to overcome tumo...

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Detalles Bibliográficos
Autores principales: Holcomb, Erin A., Zou, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803318/
https://www.ncbi.nlm.nih.gov/pubmed/35104808
http://dx.doi.org/10.1172/JCI156628