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A forced marriage of IL-2 and PD-1 antibody nurtures tumor-infiltrating T cells
IL-2 is a pleiotropic cytokine. In this issue of the JCI, Ren et al. report on the development of a low-affinity IL-2 paired with anti–PD-1 (PD-1–laIL-2) that reactivates intratumoral CD8(+) T cells, but not CD4(+) Treg cells. PD-1–laIL-2 treatment synergized with anti–PD-L1 therapy to overcome tumo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Clinical Investigation
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803318/ https://www.ncbi.nlm.nih.gov/pubmed/35104808 http://dx.doi.org/10.1172/JCI156628 |