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Cellular senescence and the skeleton: pathophysiology and therapeutic implications

Cellular senescence is a fundamental aging mechanism that is currently the focus of considerable interest as a pathway that could be targeted to ameliorate aging across multiple tissues, including the skeleton. There is now substantial evidence that senescent cells accumulate in the bone microenviro...

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Detalles Bibliográficos
Autores principales: Khosla, Sundeep, Farr, Joshua N., Monroe, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803328/
https://www.ncbi.nlm.nih.gov/pubmed/35104801
http://dx.doi.org/10.1172/JCI154888