JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Oligodendrocytes are the primary target of demyelinating disorders, and progressive neurodegenerative changes may evolve in the CNS. DNA damage and oxidative stress are considered key pathogenic events, but the underlying molecular mechanisms remain unclear. Moreover, animal models do not fully reca...

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Detalles Bibliográficos
Autores principales: Rivellini, Cristina, Porrello, Emanuela, Dina, Giorgia, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Bacigaluppi, Marco, Gullotta, Giorgia Serena, Chaabane, Linda, Leocani, Letizia, Marenna, Silvia, Colombo, Emanuela, Farina, Cinthia, Newcombe, Jia, Nave, Klaus-Armin, Pardi, Ruggero, Quattrini, Angelo, Previtali, Stefano C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803330/
https://www.ncbi.nlm.nih.gov/pubmed/34874913
http://dx.doi.org/10.1172/JCI145071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803330/
https://www.ncbi.nlm.nih.gov/pubmed/34874913
http://dx.doi.org/10.1172/JCI145071

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