An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP

It has been revealed that 2′3′-cyclic-GMP-AMP (cGAMP), a second messenger that activates the antiviral stimulator of IFN genes (STING), elicits an antitumoral immune response. Since cGAMP cannot cross the cell membrane, it is not clear how intracellular STING has been activated by extracellular cGAM...

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Detalles Bibliográficos
Autores principales: Li, Xiaobo, Zhu, Yuanyuan, Zhang, Xiao, An, Xiang, Weng, Mingjiao, Shi, Jiaqi, Wang, Song, Liu, Caiqi, Luo, Shengnan, Zheng, Tongsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803335/
https://www.ncbi.nlm.nih.gov/pubmed/34905508
http://dx.doi.org/10.1172/JCI144339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803335/
https://www.ncbi.nlm.nih.gov/pubmed/34905508
http://dx.doi.org/10.1172/JCI144339

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