Smad7 effects on TGF-β and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure

Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts. However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to prevent excessive fibrosis and adverse remodeling that may precipitate heart failure. We hypothesized that induction of the...

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Detalles Bibliográficos
Autores principales: Humeres, Claudio, Shinde, Arti V., Hanna, Anis, Alex, Linda, Hernández, Silvia C., Li, Ruoshui, Chen, Bijun, Conway, Simon J., Frangogiannis, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803336/
https://www.ncbi.nlm.nih.gov/pubmed/34905511
http://dx.doi.org/10.1172/JCI146926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803336/
https://www.ncbi.nlm.nih.gov/pubmed/34905511
http://dx.doi.org/10.1172/JCI146926

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