Confirmatory detection of neutralizing antibodies to AAV gene therapy using a cell-based transduction inhibition assay

Successful treatment with adeno-associated virus (AAV)-based gene therapies can be limited by pre-existing anti-AAV antibodies. Cell-based transduction inhibition (TI) assays are useful to characterize the neutralizing potential of anti-AAV antibodies in patient samples. While these assays are commo...

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Detalles Bibliográficos
Autores principales: Kasprzyk, Theresa, Triffault, Sabrina, Long, Brian R., Zoog, Stephen J., Vettermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803586/
https://www.ncbi.nlm.nih.gov/pubmed/35141351
http://dx.doi.org/10.1016/j.omtm.2022.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803586/
https://www.ncbi.nlm.nih.gov/pubmed/35141351
http://dx.doi.org/10.1016/j.omtm.2022.01.004

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