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Confirmatory detection of neutralizing antibodies to AAV gene therapy using a cell-based transduction inhibition assay

Successful treatment with adeno-associated virus (AAV)-based gene therapies can be limited by pre-existing anti-AAV antibodies. Cell-based transduction inhibition (TI) assays are useful to characterize the neutralizing potential of anti-AAV antibodies in patient samples. While these assays are commo...

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Detalles Bibliográficos
Autores principales:	Kasprzyk, Theresa, Triffault, Sabrina, Long, Brian R., Zoog, Stephen J., Vettermann, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803586/ https://www.ncbi.nlm.nih.gov/pubmed/35141351 http://dx.doi.org/10.1016/j.omtm.2022.01.004

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