Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival

Hypertrophic/dilated cardiomyopathy, often a prequel to heart failure, is accompanied by maladaptive transcriptional changes that contribute to arrythmias and contractile misfunction. Transgenic mice constitutively expressing high levels of calcineurin are known to develop extreme heart hypertrophy,...

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Detalles Bibliográficos
Autores principales: Tran, Tram Anh, Zhang, Qing-Jun, Wang, Lei, Gonzales, Christopher, Girard, Luc, May, Herman, Gillette, Thomas, Liu, Zhi-Ping, Martinez, Elisabeth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803621/
https://www.ncbi.nlm.nih.gov/pubmed/34933013
http://dx.doi.org/10.1016/j.jbc.2021.101515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803621/
https://www.ncbi.nlm.nih.gov/pubmed/34933013
http://dx.doi.org/10.1016/j.jbc.2021.101515

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