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Fibroblast activation protein targeted therapy using [(177)Lu]FAPI-46 compared with [(225)Ac]FAPI-46 in a pancreatic cancer model

PURPOSE: Fibroblast activation protein (FAP), which has high expression in cancer-associated fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study used (64)Cu and (225)Ac-labelled FAP inhibitors (FAPI-04) for a FAP-expressing pancreatic cancer xenograft imaging a...

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Detalles Bibliográficos
Autores principales: Liu, Yuwei, Watabe, Tadashi, Kaneda-Nakashima, Kazuko, Shirakami, Yoshifumi, Naka, Sadahiro, Ooe, Kazuhiro, Toyoshima, Atsushi, Nagata, Kojiro, Haberkorn, Uwe, Kratochwil, Clemens, Shinohara, Atsushi, Hatazawa, Jun, Giesel, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803706/
https://www.ncbi.nlm.nih.gov/pubmed/34537893
http://dx.doi.org/10.1007/s00259-021-05554-2