Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

Topoisomerase IIIα is a type 1A topoisomerase that forms a complex with RMI1 and RMI2 called TRR in human cells. TRR plays an essential role in resolving DNA replication and recombination intermediates, often alongside the helicase BLM. While the TRR catalytic cycle is known to involve a protein-med...

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Detalles Bibliográficos
Autores principales: Bakx, Julia A. M., Biebricher, Andreas S., King, Graeme A., Christodoulis, Panagiotis, Sarlós, Kata, Bizard, Anna H., Hickson, Ian D., Wuite, Gijs J. L., Peterman, Erwin J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803869/
https://www.ncbi.nlm.nih.gov/pubmed/35102151
http://dx.doi.org/10.1038/s41467-022-28082-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803869/
https://www.ncbi.nlm.nih.gov/pubmed/35102151
http://dx.doi.org/10.1038/s41467-022-28082-5

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