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Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
Topoisomerase IIIα is a type 1A topoisomerase that forms a complex with RMI1 and RMI2 called TRR in human cells. TRR plays an essential role in resolving DNA replication and recombination intermediates, often alongside the helicase BLM. While the TRR catalytic cycle is known to involve a protein-med...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803869/ https://www.ncbi.nlm.nih.gov/pubmed/35102151 http://dx.doi.org/10.1038/s41467-022-28082-5 |