Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica

Substrate inhibition of enzymes can be a major obstacle to the production of valuable chemicals in engineered microorganisms. Here, we show substrate inhibition of lycopene cyclase as the main limitation in carotenoid biosynthesis in Yarrowia lipolytica. To overcome this bottleneck, we exploit two i...

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Detalles Bibliográficos
Autores principales: Ma, Yongshuo, Liu, Nian, Greisen, Per, Li, Jingbo, Qiao, Kangjian, Huang, Sanwen, Stephanopoulos, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803881/
https://www.ncbi.nlm.nih.gov/pubmed/35102143
http://dx.doi.org/10.1038/s41467-022-28277-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803881/
https://www.ncbi.nlm.nih.gov/pubmed/35102143
http://dx.doi.org/10.1038/s41467-022-28277-w

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