Exogenous polyserine and polyleucine are toxic to recipient cells

Repeat-associated non-AUG (RAN) translation of mRNAs/transcripts responsible for polyglutamine (polyQ) diseases may generate peptides containing different mono amino acid tracts such as polyserine (polyS) and polyleucine (polyL). The propagation of aggregated polyQ from one cell to another is also a...

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Detalles Bibliográficos
Autores principales: Owada, Ryuji, Mitsui, Shinichi, Nakamura, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803884/
https://www.ncbi.nlm.nih.gov/pubmed/35102230
http://dx.doi.org/10.1038/s41598-022-05720-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803884/
https://www.ncbi.nlm.nih.gov/pubmed/35102230
http://dx.doi.org/10.1038/s41598-022-05720-y

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