POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance

Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1. Here we provide evidence of POT1 plasticity that contributes to its lack of stability in the absen...

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Detalles Bibliográficos
Autores principales: Aramburu, Tomas, Kelich, Joseph, Rice, Cory, Skordalakes, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803944/
https://www.ncbi.nlm.nih.gov/pubmed/35140887
http://dx.doi.org/10.1016/j.csbj.2022.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803944/
https://www.ncbi.nlm.nih.gov/pubmed/35140887
http://dx.doi.org/10.1016/j.csbj.2022.01.005

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