TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import

To combat nutritional immunity, N. gonorrhoeae has evolved systems to hijack zinc and other metals directly from host metal-binding proteins such as calprotectin (CP). Here, we report the 6.1 Å cryoEM structure of the gonococcal surface receptor TdfH in complex with a zinc-bound CP tetramer. We furt...

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Detalles Bibliográficos
Autores principales: Bera, Aloke K., Wu, Runrun, Harrison, Simone, Cornelissen, Cynthia Nau, Chazin, Walter J., Noinaj, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803948/
https://www.ncbi.nlm.nih.gov/pubmed/35102276
http://dx.doi.org/10.1038/s42003-022-03039-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803948/
https://www.ncbi.nlm.nih.gov/pubmed/35102276
http://dx.doi.org/10.1038/s42003-022-03039-y

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