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Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation

The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures. However, the effects of manipulating HIF-1α pathway on bone micro-structure and remodeling should be fully studied before the cl...

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Autores principales: Chen, Kaizhe, Zhao, Jian, Qiu, Minglong, Zhang, Lianfang, Yang, Kai, Chang, Leilei, Jia, Peng, Qi, Jin, Deng, Lianfu, Li, Changwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804240/
https://www.ncbi.nlm.nih.gov/pubmed/35118061
http://dx.doi.org/10.3389/fcell.2021.721561
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author Chen, Kaizhe
Zhao, Jian
Qiu, Minglong
Zhang, Lianfang
Yang, Kai
Chang, Leilei
Jia, Peng
Qi, Jin
Deng, Lianfu
Li, Changwei
author_facet Chen, Kaizhe
Zhao, Jian
Qiu, Minglong
Zhang, Lianfang
Yang, Kai
Chang, Leilei
Jia, Peng
Qi, Jin
Deng, Lianfu
Li, Changwei
author_sort Chen, Kaizhe
collection PubMed
description The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures. However, the effects of manipulating HIF-1α pathway on bone micro-structure and remodeling should be fully studied before the clinical application of therapeutics that interfere with the HIF-1α pathway. In this study, we found that osteocyte-specific HIF-1α pathway had critical role in manipulating bone mass accrual, bone material properties and micro-structures, including bone mineralization, bone collagen fiber formation, osteocyte/canalicular network, and bone remodeling. In addition, our results suggest that osteocyte-specific HIF-1α pathway regulates bone micro-structure and remodeling via impairing osteocyte differentiation and maturation.
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spelling pubmed-88042402022-02-02 Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation Chen, Kaizhe Zhao, Jian Qiu, Minglong Zhang, Lianfang Yang, Kai Chang, Leilei Jia, Peng Qi, Jin Deng, Lianfu Li, Changwei Front Cell Dev Biol Cell and Developmental Biology The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures. However, the effects of manipulating HIF-1α pathway on bone micro-structure and remodeling should be fully studied before the clinical application of therapeutics that interfere with the HIF-1α pathway. In this study, we found that osteocyte-specific HIF-1α pathway had critical role in manipulating bone mass accrual, bone material properties and micro-structures, including bone mineralization, bone collagen fiber formation, osteocyte/canalicular network, and bone remodeling. In addition, our results suggest that osteocyte-specific HIF-1α pathway regulates bone micro-structure and remodeling via impairing osteocyte differentiation and maturation. Frontiers Media S.A. 2022-01-18 /pmc/articles/PMC8804240/ /pubmed/35118061 http://dx.doi.org/10.3389/fcell.2021.721561 Text en Copyright © 2022 Chen, Zhao, Qiu, Zhang, Yang, Chang, Jia, Qi, Deng and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chen, Kaizhe
Zhao, Jian
Qiu, Minglong
Zhang, Lianfang
Yang, Kai
Chang, Leilei
Jia, Peng
Qi, Jin
Deng, Lianfu
Li, Changwei
Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title_full Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title_fullStr Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title_full_unstemmed Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title_short Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation
title_sort osteocytic hif-1α pathway manipulates bone micro-structure and remodeling via regulating osteocyte terminal differentiation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804240/
https://www.ncbi.nlm.nih.gov/pubmed/35118061
http://dx.doi.org/10.3389/fcell.2021.721561
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