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sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency. However, experimental evidence for the establishment of sgRNA knock-in animals and ana...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804526/ https://www.ncbi.nlm.nih.gov/pubmed/35118065 http://dx.doi.org/10.3389/fcell.2021.769673 |