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sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency. However, experimental evidence for the establishment of sgRNA knock-in animals and ana...

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Detalles Bibliográficos
Autores principales:	Zhang, Lichen, Li, Wushan, Liu, Zhuangzhuang, Liu, Yang, Liu, Zhilong, Gu, Yanrong, He, Le, Zhou, Binhui, Li, Tianhan, Chao, Tianzhu, Liang, Yinming, Lu, Liaoxun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804526/ https://www.ncbi.nlm.nih.gov/pubmed/35118065 http://dx.doi.org/10.3389/fcell.2021.769673

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