Reversible switching of leukemic cells to a drugresistant, stem-like subset via IL-4-mediated cross-talk with mesenchymal stroma

Chemoresistance of leukemic cells has largely been attributed to clonal evolution secondary to accumulating mutations. Here, we show that a subset of leukemic blasts in contact with the mesenchymal stroma undergo cellular conversion into a distinct cell type that exhibits a stem cell-like phenotype...

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Detalles Bibliográficos
Autores principales: Lee, Hae-Ri, Lee, Ga-Young, Kim, Eung-Won, Kim, Hee-Je, Lee, Minho, Humphries, R. Keith, Oh, Il-Hoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804570/
https://www.ncbi.nlm.nih.gov/pubmed/33440923
http://dx.doi.org/10.3324/haematol.2020.269944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804570/
https://www.ncbi.nlm.nih.gov/pubmed/33440923
http://dx.doi.org/10.3324/haematol.2020.269944

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