CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide

There is a strong biological rationale for the augmentation of allogeneic natural killer (NK) cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia (AML) targeting. CD38 is an established immunotherapeutic target in multiple myeloma and under investigation as a targ...

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Detalles Bibliográficos
Autores principales: Gurney, Mark, Stikvoort, Arwen, Nolan, Emma, Kirkham-McCarthy, Lucy, Khoruzhenko, Stanislav, Shivakumar, Rama, Zweegman, Sonja, van de Donk, Niels W.C.J., Mutis, Tuna, Szegezdi, Eva, Sarkar, Subhashis, O’Dwyer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804573/
https://www.ncbi.nlm.nih.gov/pubmed/33375774
http://dx.doi.org/10.3324/haematol.2020.271908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804573/
https://www.ncbi.nlm.nih.gov/pubmed/33375774
http://dx.doi.org/10.3324/haematol.2020.271908

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