APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

APR-246 is a promising new therapeutic agent that targets p53 mutated proteins in myelodysplastic syndromes and in acute myeloid leukemia (AML). APR-246 reactivates the transcriptional activity of p53 mutants by facilitating their binding to DNA target sites. Recent studies in solid cancers have fou...

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Detalles Bibliográficos
Autores principales: Birsen, Rudy, Larrue, Clement, Decroocq, Justine, Johnson, Natacha, Guiraud, Nathan, Gotanegre, Mathilde, Cantero-Aguilar, Lilia, Grignano, Eric, Huynh, Tony, Fontenay, Michaela, Kosmider, Olivier, Mayeux, Patrick, Chapuis, Nicolas, Sarry, Jean Emmanuel, Tamburini, Jerome, Bouscary, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804578/
https://www.ncbi.nlm.nih.gov/pubmed/33406814
http://dx.doi.org/10.3324/haematol.2020.259531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804578/
https://www.ncbi.nlm.nih.gov/pubmed/33406814
http://dx.doi.org/10.3324/haematol.2020.259531

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