4,5,7‐Trisubstituted indeno[1,2‐b]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects

Highly pleiotropic and constitutively active protein kinase CK2 is a key target in cancer therapy, but only one small‐molecule inhibitor has reached clinical trials—CX‐4945. In this study, we present the indeno[1,2‐b]indole derivative 5‐isopropyl‐4‐methoxy‐7‐methyl‐5,6,7,8‐tetrahydroindeno[1,2‐b]ind...

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Detalles Bibliográficos
Autores principales: Birus, Robin, El‐Awaad, Ehab, Ballentin, Laurens, Alchab, Faten, Aichele, Dagmar, Ettouati, Laurent, Götz, Claudia, Le Borgne, Marc, Jose, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804612/
https://www.ncbi.nlm.nih.gov/pubmed/34873879
http://dx.doi.org/10.1002/2211-5463.13346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804612/
https://www.ncbi.nlm.nih.gov/pubmed/34873879
http://dx.doi.org/10.1002/2211-5463.13346

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