VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear. Recently, the role of voltage‐dependent anion channel protein 1 (VDAC1) in mitochondrial activity and cell apoptosis has attracted much att...

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Detalles Bibliográficos
Autores principales: Zhu, Xueqin, Luo, Lei, Xiong, Yanyan, Jiang, Nan, Wang, Yurun, Lv, Yuan, Xie, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804618/
https://www.ncbi.nlm.nih.gov/pubmed/34967508
http://dx.doi.org/10.1002/2211-5463.13359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8804618/
https://www.ncbi.nlm.nih.gov/pubmed/34967508
http://dx.doi.org/10.1002/2211-5463.13359

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