Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined. In this study, we utilized a genome-wide approach...

Descripción completa

Detalles Bibliográficos
Autores principales: Thiede, Joshua M., Dillon, Nicholas A., Howe, Michael D., Aflakpui, Ranee, Modlin, Samuel J., Hoffner, Sven E., Valafar, Faramarz, Minato, Yusuke, Baughn, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805019/
https://www.ncbi.nlm.nih.gov/pubmed/35100871
http://dx.doi.org/10.1128/mbio.00439-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805019/
https://www.ncbi.nlm.nih.gov/pubmed/35100871
http://dx.doi.org/10.1128/mbio.00439-21

Ejemplares similares