Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens

Nanoparticle (NP) vaccine formulations promote immune responses through multiple mechanisms. We recently reported that mannose-binding lectin (MBL) triggers trafficking of glycosylated HIV Env-immunogen NPs to lymph node follicles. Here, we investigate effects of MBL and complement on NP forms of HI...

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Detalles Bibliográficos
Autores principales: Read, Benjamin J., Won, Lori, Kraft, John C., Sappington, Isaac, Aung, Aereas, Wu, Shengwei, Bals, Julia, Chen, Chengbo, Lee, Kelly K., Lingwood, Daniel, King, Neil P., Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805147/
https://www.ncbi.nlm.nih.gov/pubmed/35021101
http://dx.doi.org/10.1016/j.celrep.2021.110217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805147/
https://www.ncbi.nlm.nih.gov/pubmed/35021101
http://dx.doi.org/10.1016/j.celrep.2021.110217

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