Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis

BACKGROUND: Multiple myeloma (MM) remains an incurable cancer despite advances in therapy. Therefore, the search for new targets is still essential to uncover potential treatment strategies. Metabolic changes, induced by the hypoxic bone marrow, contribute to both MM cell survival and drug resistanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Oudaert, Inge, Satilmis, Hatice, Vlummens, Philip, De Brouwer, Wouter, Maes, Anke, Hose, Dirk, De Bruyne, Elke, Ghesquière, Bart, Vanderkerken, Karin, De Veirman, Kim, Menu, Eline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805317/
https://www.ncbi.nlm.nih.gov/pubmed/35105345
http://dx.doi.org/10.1186/s13046-022-02250-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805317/
https://www.ncbi.nlm.nih.gov/pubmed/35105345
http://dx.doi.org/10.1186/s13046-022-02250-3

Ejemplares similares