LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (ALP), defects of which are associated with α-synuclein (α-syn) accumulation. LRRK2 regula...

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Detalles Bibliográficos
Autores principales: Pang, Shirley Yin-Yu, Lo, Rachel Cheuk Nam, Ho, Philip Wing-Lok, Liu, Hui-Fang, Chang, Eunice Eun Seo, Leung, Chi-Ting, Malki, Yasine, Choi, Zoe Yuen-Kiu, Wong, Wing Yan, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805403/
https://www.ncbi.nlm.nih.gov/pubmed/35101134
http://dx.doi.org/10.1186/s40035-022-00281-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805403/
https://www.ncbi.nlm.nih.gov/pubmed/35101134
http://dx.doi.org/10.1186/s40035-022-00281-6

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