A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

BACKGROUND: Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities. Therefore, an in silico humanization method that can prevent the loss of the binding affinity of mAbs is needed. METHODS...

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Detalles Bibliográficos
Autores principales: Hsieh, Yuan-Chin, Liao, Jun-min, Chuang, Kuo-Hsiang, Ho, Kai-Wen, Hong, Shih-Ting, Liu, Hui-Ju, Huang, Bo-Cheng, Chen, I-Ju, Liu, Yen-Ling, Wang, Jaw-Yuan, Tsai, Hsiang-Lin, Su, Yu-Cheng, Wang, Yen-Tseng, Cheng, Tian-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805405/
https://www.ncbi.nlm.nih.gov/pubmed/35101043
http://dx.doi.org/10.1186/s12951-022-01259-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805405/
https://www.ncbi.nlm.nih.gov/pubmed/35101043
http://dx.doi.org/10.1186/s12951-022-01259-2

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