Cargando…

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

BACKGROUND: Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities. Therefore, an in silico humanization method that can prevent the loss of the binding affinity of mAbs is needed. METHODS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsieh, Yuan-Chin, Liao, Jun-min, Chuang, Kuo-Hsiang, Ho, Kai-Wen, Hong, Shih-Ting, Liu, Hui-Ju, Huang, Bo-Cheng, Chen, I-Ju, Liu, Yen-Ling, Wang, Jaw-Yuan, Tsai, Hsiang-Lin, Su, Yu-Cheng, Wang, Yen-Tseng, Cheng, Tian-Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805405/ https://www.ncbi.nlm.nih.gov/pubmed/35101043 http://dx.doi.org/10.1186/s12951-022-01259-2

Ejemplares similares

Editorial: The Evolving Landscape, Clinical Implications, and Future Perspective of Biomarkers in Gastrointestinal Cancers
por: Tsai, Hsiang-Lin, et al.
Publicado: (2022)

An Innovative Ultrasonic Apparatus and Technology for Diagnosis of Freeze-Drying Process
por: Cheng, Chin-Chi, et al.
Publicado: (2019)

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy
por: Lu, Yun-Chi, et al.
Publicado: (2019)

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles
por: Hsieh, Yuan-Chin, et al.
Publicado: (2016)

A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab
por: Chang, Tsung-Kun, et al.
Publicado: (2021)

Discovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening
por: Cheng, Ta-Chun, et al.
Publicado: (2015)

Observational Study Comparing Efficacy and Safety between Neoadjuvant Concurrent Chemoradiotherapy and Chemotherapy for Patients with Unresectable Locally Advanced or Metastatic Gastric Cancer
por: Yeh, Yung-Sung, et al.
Publicado: (2020)

Novel Real-Time Diagnosis of the Freezing Process Using an Ultrasonic Transducer
por: Tseng, Yen-Hsiang, et al.
Publicado: (2015)

Development and evaluation of a monoclonal antibody-based competitive ELISA for the detection of antibodies against H7 avian influenza virus
por: Li, Yuan, et al.
Publicado: (2021)

A rapid and scalable method for selecting recombinant mouse monoclonal antibodies
por: Crosnier, Cécile, et al.
Publicado: (2010)

In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer Population
por: Liu, Li-Yu D, et al.
Publicado: (2012)

IRSS: a web-based tool for automatic layout and analysis of IRES secondary structure prediction and searching system in silico
por: Wu, Tzong-Yuan, et al.
Publicado: (2009)

A New Microsphere-Based Immunoassay for Measuring the Activity of Transcription Factors
por: Lin, Yu-Ling, et al.
Publicado: (2010)

A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies
por: Chen, Qin, et al.
Publicado: (2018)

Author Correction: Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays
por: Hao, Wen-Rui, et al.
Publicado: (2018)

Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays
por: Hao, Wen-Rui, et al.
Publicado: (2017)

Unusual paediatric sigmoid perivascular epithelioid cell tumour with regional lymph node metastasis treated using gemcitabine and docetaxel: a case report and literature review
por: Cheng, Hsiu-Chung, et al.
Publicado: (2021)

Detecting variable (V), diversity (D) and joining (J) gene segment recombination using a two-colour fluorescence system
por: Scott, Gina B, et al.
Publicado: (2010)

Antigenicity and receptor-binding ability of recombinant SARS coronavirus spike protein
por: Ho, Tin-Yun, et al.
Publicado: (2004)

Comparison of the developmental potential of 2-week-old preantral follicles derived from vitrified ovarian tissue slices, vitrified whole ovaries and vitrified/transplanted newborn mouse ovaries using the metal surface method
por: Lin, Ta-Chin, et al.
Publicado: (2008)

Stressed portfolio optimization with semiparametric method
por: Han, Chuan-Hsiang, et al.
Publicado: (2022)

CirPred, the first structure modeling and linker design system for circularly permuted proteins
por: Chen, Teng-Ruei, et al.
Publicado: (2021)

Viral Pneumonia during the COVID-19 Pandemic, 2019–2021 Evoking Needs for SARS-CoV-2 and Additional Vaccinations
por: Lin, Sheng-Chieh, et al.
Publicado: (2023)

Robot-Assisted Radiofrequency Ablation Combined with Thermodynamic Simulation for Epilepsy Reoperations
por: Wang, Yu-Chi, et al.
Publicado: (2022)

Semantically Linking In Silico Cancer Models
por: Johnson, David, et al.
Publicado: (2014)

Fast multiclonal clusterization of V(D)J recombinations from high-throughput sequencing
por: Giraud, Mathieu, et al.
Publicado: (2014)

An efficient RNA interference screening strategy for gene functional analysis
por: Chang, Chih-Hung, et al.
Publicado: (2012)

Rectal Carcinoma in a Young Female Patient with Peutz-Jeghers Syndrome: A Case Report
por: Tsai, Hsiang-Lin, et al.
Publicado: (2013)

Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes
por: Cheng, Hsiu-Chung, et al.
Publicado: (2021)

Targeted parallel sequencing of large genetically-defined genomic regions for identifying mutations in Arabidopsis
por: Liu, Kun-hsiang, et al.
Publicado: (2012)

Effect of KRAS and NRAS mutations on the prognosis of patients with synchronous metastatic colorectal cancer presenting with liver-only and lung-only metastases
por: Chuang, Shih-Chang, et al.
Publicado: (2020)

Low Ligation Plus High Dissection Versus High Ligation of the Inferior Mesenteric Artery in Sigmoid Colon and Rectal Cancer Surgery: A Meta-Analysis
por: Yin, Tzu-Chieh, et al.
Publicado: (2021)

MicroRNAs as Predictive Biomarkers in Patients with Colorectal Cancer Receiving Chemotherapy or Chemoradiotherapy: A Narrative Literature Review
por: Yang, I-Ping, et al.
Publicado: (2023)

Impact of previous abdominal surgery on robotic-assisted rectal surgery in patients with locally advanced rectal adenocarcinoma: a propensity score matching study
por: Huang, Ching-Wen, et al.
Publicado: (2020)

UGT1A1 Polymorphism for Irinotecan Dose Escalation in Patients with BRAF-Mutated Metastatic Colorectal Cancer Treated with First-Line Bevacizumab and FOLFIRI
por: Hsieh, Yi-Chien, et al.
Publicado: (2021)

Protein folding prediction in the HP model using ions motion optimization with a greedy algorithm
por: Yang, Cheng-Hong, et al.
Publicado: (2018)

Melastoma malabathricum L. Suppresses Neutrophil Extracellular Trap Formation Induced by Synthetic Analog of Viral Double-Stranded RNA Associated with SARS-CoV-2 Infection
por: Huang, Tse-Hung, et al.
Publicado: (2023)

Optimized reduced representation bisulfite sequencing reveals tissue-specific mCHH islands in maize
por: Hsu, Fei-Man, et al.
Publicado: (2017)

Aqueous-Phase Hydrogenolysis of Glycerol over Re Promoted Ru Catalysts Encapuslated in Porous Silica Nanoparticles
por: Li, Kuo-Tseng, et al.
Publicado: (2018)

Time interval between the completion of radiotherapy and robotic-assisted surgery among patients with stage I–III rectal cancer undergoing preoperative chemoradiotherapy
por: Huang, Ching-Wen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2ap0flf70nrh2hsv3t4les7t3s