Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors

[Image: see text] The metalloproteinase ADAM8 is upregulated in several cancers but has a dispensable function under physiological conditions. In tumor cells, ADAM8 is involved in invasion, migration, and angiogenesis. The use of bivalent inhibitors could impair migration and invasion through the do...

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Detalles Bibliográficos
Autores principales: Cuffaro, Doretta, Camodeca, Caterina, Tuccinardi, Tiziano, Ciccone, Lidia, Bartsch, Jörg W., Kellermann, Tanja, Cook, Lena, Nuti, Elisa, Rossello, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805605/
https://www.ncbi.nlm.nih.gov/pubmed/35111280
http://dx.doi.org/10.1021/acsmedchemlett.1c00411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805605/
https://www.ncbi.nlm.nih.gov/pubmed/35111280
http://dx.doi.org/10.1021/acsmedchemlett.1c00411

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