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Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors

[Image: see text] The metalloproteinase ADAM8 is upregulated in several cancers but has a dispensable function under physiological conditions. In tumor cells, ADAM8 is involved in invasion, migration, and angiogenesis. The use of bivalent inhibitors could impair migration and invasion through the do...

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Detalles Bibliográficos
Autores principales:	Cuffaro, Doretta, Camodeca, Caterina, Tuccinardi, Tiziano, Ciccone, Lidia, Bartsch, Jörg W., Kellermann, Tanja, Cook, Lena, Nuti, Elisa, Rossello, Armando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805605/ https://www.ncbi.nlm.nih.gov/pubmed/35111280 http://dx.doi.org/10.1021/acsmedchemlett.1c00411

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