Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders

Mouse knockouts of Cntnap2 show altered neurodevelopmental behavior, deficits in striatal GABAergic signaling, and a genome-wide disruption of an environmentally sensitive DNA methylation modification (5-hydroxymethylcytosine [5hmC]) in the orthologs of a significant number of genes implicated in hu...

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Detalles Bibliográficos
Autores principales: Papale, Ligia A., Madrid, Andy, Zhang, Qi, Chen, Kailei, Sak, Lara, Keleş, Sündüz, Alisch, Reid S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805724/
https://www.ncbi.nlm.nih.gov/pubmed/34949667
http://dx.doi.org/10.1101/gr.276137.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805724/
https://www.ncbi.nlm.nih.gov/pubmed/34949667
http://dx.doi.org/10.1101/gr.276137.121

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