Cargando…

Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders

Mouse knockouts of Cntnap2 show altered neurodevelopmental behavior, deficits in striatal GABAergic signaling, and a genome-wide disruption of an environmentally sensitive DNA methylation modification (5-hydroxymethylcytosine [5hmC]) in the orthologs of a significant number of genes implicated in hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papale, Ligia A., Madrid, Andy, Zhang, Qi, Chen, Kailei, Sak, Lara, Keleş, Sündüz, Alisch, Reid S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805724/ https://www.ncbi.nlm.nih.gov/pubmed/34949667 http://dx.doi.org/10.1101/gr.276137.121

Ejemplares similares

Early-life stress links 5-hydroxymethylcytosine to anxiety-related behaviors
por: Papale, Ligia A., et al.
Publicado: (2017)

Differentially Methylated Genes in Saliva are linked to Childhood Stress
por: Papale, Ligia A., et al.
Publicado: (2018)

Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury
por: Madrid, Andy, et al.
Publicado: (2023)

Purified regenerating retinal neurons reveal regulatory role of DNA methylation-mediated Na+/K+-ATPase in murine axon regeneration
por: Rizk, Elias, et al.
Publicado: (2023)

Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences
por: Kaliman, Perla, et al.
Publicado: (2022)

Species-Specific 5 mC and 5 hmC Genomic Landscapes Indicate Epigenetic Contribution to Human Brain Evolution
por: Madrid, Andy, et al.
Publicado: (2018)

Gene-Environment Interactions in Neurodevelopmental Disorders
por: Pietropaolo, Susanna, et al.
Publicado: (2017)

Editorial: Gene and Environment Interactions in Neurodevelopmental Disorders
por: Silveira, Patrícia Pelufo, et al.
Publicado: (2022)

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation
por: Uribe-Lewis, Santiago, et al.
Publicado: (2020)

5-Methylcytosine and 5-Hydroxymethylcytosine Spatiotemporal Profiles in the Mouse Zygote
por: Salvaing, Juliette, et al.
Publicado: (2012)

Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains
por: Tang, Yilin, et al.
Publicado: (2016)

Prenatal Environment and Neurodevelopmental Disorders
por: Doi, Miyuki, et al.
Publicado: (2022)

Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
por: Dean, Douglas C., et al.
Publicado: (2021)

Sparse partial least squares regression for simultaneous dimension reduction and variable selection
por: Chun, Hyonho, et al.
Publicado: (2010)

Normalization of ChIP-seq data with control
por: Liang, Kun, et al.
Publicado: (2012)

SURF: integrative analysis of a compendium of RNA-seq and CLIP-seq datasets highlights complex governing of alternative transcriptional regulation by RNA-binding proteins
por: Chen, Fan, et al.
Publicado: (2020)

FreeHi-C simulates high fidelity Hi-C data for benchmarking and data augmentation
por: Zheng, Ye, et al.
Publicado: (2019)

Joint tensor modeling of single cell 3D genome and epigenetic data with Muscle
por: Park, Kwangmoon, et al.
Publicado: (2023)

Dozer: Debiased personalized gene co-expression networks for population-scale scRNA-seq data
por: Lu, Shan, et al.
Publicado: (2023)

Debiased personalized gene coexpression networks for population-scale scRNA-seq data
por: Lu, Shan, et al.
Publicado: (2023)

Investigating the impact of the environment on neurodevelopmental disorder
por: Volk, Heather, et al.
Publicado: (2020)

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
por: Sjöström, Martin, et al.
Publicado: (2022)

5′-methylcytosine and 5′-hydroxymethylcytosine Each Provide Epigenetic Information to the Mouse Zygote
por: Li, Yan, et al.
Publicado: (2013)

Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
por: Singh, Ratnesh K., et al.
Publicado: (2018)

5-Methylcytosine and 5-Hydroxymethylcytosine in Scrapie-Infected Sheep and Mouse Brain Tissues
por: Hernaiz, Adelaida, et al.
Publicado: (2023)

The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
por: Huang, Yun, et al.
Publicado: (2010)

Alterations of 5-Hydroxymethylcytosine in Human Cancers
por: Mariani, Christopher J., et al.
Publicado: (2013)

Formation and Abundance of 5-Hydroxymethylcytosine in RNA
por: Huber, Sabrina M, et al.
Publicado: (2015)

5-Hydroxymethylcytosine Loss in Conjunctival Melanoma
por: Stahl, Alexandre, et al.
Publicado: (2021)

The impact of the environment on neurodevelopmental disorders in early childhood
por: Scattolin, Mônica Ayres de Araújo, et al.
Publicado: (2021)

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma
por: Raiber, Eun-Ang, et al.
Publicado: (2017)

ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine
por: Schlosberg, Christopher E, et al.
Publicado: (2019)

Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
por: Lan, Jie, et al.
Publicado: (2020)

Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice
por: Chopra, Pankaj, et al.
Publicado: (2014)

Decanalization mediating gene-environment interactions in schizophrenia and other psychiatric disorders with neurodevelopmental etiology
por: Burrows, Emma L., et al.
Publicado: (2013)

Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies
por: Zheng, Ye, et al.
Publicado: (2019)

Normalization and de-noising of single-cell Hi-C data with BandNorm and scVI-3D
por: Zheng, Ye, et al.
Publicado: (2022)

AdaLiftOver: high-resolution identification of orthologous regulatory elements with Adaptive liftOver
por: Dong, Chenyang, et al.
Publicado: (2023)

Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models
por: Klibaite, Ugne, et al.
Publicado: (2022)

5-Hydroxymethylcytosines in circulating cell-free DNA reveal a diagnostic biomarker for glioma
por: Zhang, Chunyu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_asrm0u8gv9epreirstgqomnc9v