Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway

Lapatinib (LAP) is an important anti-cancer drug and is frequently alongside doxorubicin (DOX) as a combination therapy for better anti-cancer efficacy. However, many studies have reported that LAP in combination with DOX may induce highly cardiotoxicity. Accordingly, we aimed to explore the potenti...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Wang, Hua, Xu, Dan, Yu, Shanshan, Zhang, Lin, Li, Xiaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805895/
https://www.ncbi.nlm.nih.gov/pubmed/34898356
http://dx.doi.org/10.1080/21655979.2021.2004980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8805895/
https://www.ncbi.nlm.nih.gov/pubmed/34898356
http://dx.doi.org/10.1080/21655979.2021.2004980

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