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Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors
[Image: see text] SARS-CoV-2 encodes two viral cysteine proteases, the main protease (M(pro)) and the papain-like protease (PL(pro)), both of which are validated antiviral drug targets. PL(pro) is involved in the cleavage of viral polyproteins as well as immune modulation by removing ubiquitin and i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806001/ https://www.ncbi.nlm.nih.gov/pubmed/35178512 http://dx.doi.org/10.1021/acsptsci.1c00240 |