Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions

Many steps of the MHC class I antigen processing pathway can be predicted using computational methods. Here we show that epitope predictions can be further improved by considering abundance levels of peptides' source proteins. We utilized biophysical principles and existing MHC binding predicti...

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Detalles Bibliográficos
Autores principales: Koşaloğlu-Yalçın, Zeynep, Lee, Jenny, Greenbaum, Jason, Schoenberger, Stephen P., Miller, Aaron, Kim, Young J., Sette, Alessandro, Nielsen, Morten, Peters, Bjoern
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806398/
https://www.ncbi.nlm.nih.gov/pubmed/35128348
http://dx.doi.org/10.1016/j.isci.2022.103850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806398/
https://www.ncbi.nlm.nih.gov/pubmed/35128348
http://dx.doi.org/10.1016/j.isci.2022.103850

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