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Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions
Many steps of the MHC class I antigen processing pathway can be predicted using computational methods. Here we show that epitope predictions can be further improved by considering abundance levels of peptides' source proteins. We utilized biophysical principles and existing MHC binding predicti...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806398/ https://www.ncbi.nlm.nih.gov/pubmed/35128348 http://dx.doi.org/10.1016/j.isci.2022.103850 |